Hotspots of human mutation point to clonal expansions in spermatogonia

Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09579-7A systematic statistical genetics approach discovers CES drivers as hotspots of human de novo mutation and shows that clonal expansions in germline may both modulate the prevalence of disorders and lead to false-positive disease associations.  Read original aricle: Read More